GSReg: A Package for Gene Set Variability Analysis
نویسندگان
چکیده
The GSReg package allows to analyze pathways based on the variability of the expression of sets of genes that are targets of those pathways. Basing this set statistic on variability enables inference of dysregulated pathways in diseases, including notably cancers. The first set statistic for gene variability was in the work of Eddy and his colleagues (see [1]) which used a ranked based methodology called DIRAC. DIRAC calculates a measure of variability of the ordering of the expression of genes in a pathway for specific phenotype. The basic idea behind DIRAC is to generate a template for the pair-wise comparisons of gene expressions
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